Cresco was a stage stop between Hyatt and Mineral Point stage stop on the Leavenworth to Dodge City Stage line. The town was founded in May, 1857. The post office in Cresco was the third in Anderson County. The town had a blacksmith shop and a wagon shop. There was a branch of the Pottawatomie Creek close to Cresco and a steam sawmill was built on it. In 1859 most citizens of Cresco caught the "Pike's Peak Gold Fever" and left Cresco and went west to Colorado. There is no evidence left of a townsite.